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Inoculation was introduced to America by a slave



Few details are known about the birth of Onesimus, but it is assumed he was born in Africa in the late seventeenth century before eventually landing in Boston. One of a thousand people of African descent living in the Massachusetts colony, Onesimus was a gift to the Puritan church minister Cotton Mather from his congregation in 1706.

Onesimus told Mather about the centuries old tradition of inoculation practiced in Africa. By extracting the material from an infected person and scratching it into the skin of an uninfected person, you could deliberately introduce smallpox to the healthy individual making them immune. Considered extremely dangerous at the time, Cotton Mather convinced Dr. Zabdiel Boylston to experiment with the procedure when a smallpox epidemic hit Boston in 1721 and over 240 people were inoculated. Opposed politically, religiously and medically in the United States and abroad, public reaction to the experiment put Mather and Boylston’s lives in danger despite records indicating that only 2% of patients requesting inoculation died compared to the 15% of people not inoculated who contracted smallpox.
Onesimus’ traditional African practice was used to inoculate American soldiers during the Revolutionary War and introduced the concept of inoculation to the United States. 

Reports of similar practices in Turkey further persuaded Mather to mount a public inoculation campaign. Most white doctors rejected this process of deliberately infecting a person with smallpox--now called variolation--in part because of their misgivings about African medical knowledge. Public and medical opinion in Boston was strongly against both Mather and Dr. Zabdiel Boylston, the only doctor in town willing to perform inoculations; one opponent even threw a grenade into Mather’s home. A survey of the nearly six thousand people who contracted smallpox between 1721 and 1723 found, however, that Onesimus, Mather, and Boylston had been right. Only 2 percent of the six hundred Bostonians inoculated against smallpox died, while 14 percent of those who caught the disease but were not inoculated succumbed to the illness.

It is unclear when or how Onesimus died, but his legacy is unambiguous. His knowledge of variolation gives the lie to one justification for enslaving Africans, namely, white Europeans’ alleged superiority in medicine, science, and technology. This bias made the smallpox epidemic of 1721 more deadly than it need have been. Bostonians and other Americans nonetheless adopted the African practice of inoculation in future smallpox outbreaks, and variolation remained the most effective means of treating the disease until the development of vaccination by Edward Jenner in 1796.

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